Genetic variations in the Orf7a protein of SARS-CoV-2 and its possible role in vaccine development
The recurrent mutations in Orf7a of SARS-CoV-2 provide a deep understanding of its role in the virus–host interactions. Findings of our study revealed that the predicted epitopes could be promising candidates for a vaccine against COVID-19 infections.....
Docking studies, synthesis, characterization, and cytotoxicity activity of new bis-chalcones derivatives
The cytotoxic activity of all the synthesized compounds was evaluated against MCF-7 breast cancer cell lines. Compounds 5 and 6 were found to have IC50 values of about 20 µM. These compounds are good candidates to be selected for further studies to develop anticancer drugs...
Effects of ethanol extracts of Diodia sarmentosa leaves on biochemical and histopathological indices of monosodium glutamate-induced uterine leiomyoma in rats
Summary: Diodia sarmentosa leaves have gained application in the local treatment of certain ailments. This study evaluated the effect of ethanol extracts of Diodia sarmentosa leaves on biochemical, antioxidant, and histopathological indices of monosodium glutamate-induced uterine leiomyoma in albino rats.
Assessment of the safety and effectiveness of the first sirolimus stent manufactured in Viet Nam
Summary: To evaluate the effectiveness and safety of the first sirolimus-eluting stent made in Vietnam (Xplosion stent) on Vietnamese patients via the following outcomes: restenosis rate in the stent and at the two heads of stent, stent occlusion rate, and mortality rate due to myocardial infarction at 6 months and 12 months following stent placement.
Green Synthesis of RES-CMCS: A Promising Modulator of the GLUT-4/Leptin Signaling Pathway in HFD-induced Insulin Resistance
Summary: Resveratrol (RES) is a multi-biofunctional compound found in grapes and mulberries. The present investigation was aimed at the green synthesis of resveratrol-carboxymethyl nanoparticles using low viscosity chitosan (RES-CMCS) and evaluation of their antidiabetic and antiobesity activity.
In silico and in vitro analysis of differentially expressed microRNAs, circular RNAs, and p53 in bortezomib-resistant multiple myeloma
Summary: Multiple myeloma (MM), which constitutes 1% of all cancers, remains incurable due to the acquisition of drug resistance. Proteasome inhibitor therapy such as bortezomib (BTZ), one of the key therapies used to treat MM, is impeded by the occurrence of BTZ resistance. The precise mechanism underlying this acquired BTZ resistance in MM is not yet well understood. In recent times, the role of non-coding RNAs, such as microRNAs (miRNAs) and circular RNAs (circRNAs), in cancer progression and drug resistance has been demonstrated. The present study aimed to identify differentially expressed miRNAs (DEmiRs), circRNAs, and target genes in BTZ-resistant MM in silico and in vitro.
Left ventricular noncompaction cardiomyopathy associated with severe coronary artery disease: a case report
Summary: Left ventricular noncompaction, or noncompaction cardiomyopathy, is a rare congenital cardiomyopathy caused by the failure of the myocardial compaction. It has distinct morphological characteristics in the ventricular cavity and main cclinical manifestations are heart failure, arrhythmia, and thromboembolic complications. This paper reports on a patient who was admitted to the hospital with a diagnosis of acute myocardial infarction and severe left ventricular systolic dysfunction. During the patient's assessment and investigation, left ventricular noncompaction cardiomyopathy was diagnosed. In this literature review, we discuss the diagnostic criteria and the treatment of these patients.
Serum Vitamin D and Anti-Cyclic Citrullinated Peptide Levels in Rheumatoid Arthritis Patients
Summary: Rheumatoid arthritis (RA) is long-term autoimmune disorder that primarily affects the joints. Vitamin D has a role in the activity and pathogenesis of RA. The aim of this study is to determine the correlation of vitamin D and anti-cyclic citrullinated peptide (anti-CCP) with disease activity in RA patients.
Increased Neuron Specific Enolase in a Hypoxic Ischemia Rat Model
Summary: Acute brain injury caused by cerebral ischemia, either due to stroke or ischemic hypoxic-ischemic encephalopathy (HIE), represents a major neurological cause of death and disability worldwide. Neuronal cell injury has been shown to correlate with a significant increase in neuron-specific enolase (NSE) levels in in vitro studies. This study aims to measure NSE levels in the blood serum of rats with HIE.
The relationship between PD-L1 expression and clinicopathological characteristics and prognosis of Vietnamese gastric cancer patients
Summary: Programmed Death Ligand 1 (PD-L1) is a putative biomarker response to an immune checkpoint blockade that is related to poor outcomes as well as treatment strategy of numerous carcinomas, including gastric cancer. However, there is still a lack of other biomarkers that can predict patient prognosis in clinical settings. For this reason, we investigated PD-L1 expression and Combined Positive Score (CPS), as well its association with histopathological characteristics in gastric cancer patients.
Comparison of the pain-killing effects of leech therapy versus physiotherapy in patients with knee osteoarthritis: A double-blind randomized clinical trial
Summary: Knee osteoarthritis is a debilitating disease that affects a large proportion of the elderly population. Treatments for this disease are mostly based on symptomatic management. The primary treatments are physiotherapy, which is associated with high costs, and nonsteroidal antiinflammatory drugs (NSAIDs), which have serious side effects, including gastrointestinal bleeding, renal failure, and cardiovascular complications. This study aimed to assess the effects of leech therapy versus physiotherapy as a noninvasive method in the treatment of knee osteoarthritis.
Onion Peel Quercetin Attenuates Ethanol-Induced Liver Injury in Mice by Preventing Oxidative Stress and Steatosis
Summary: Alcoholic liver disease (ALD) is a histological abnormality of the liver that ranges from steatosis to fibrosis/cirrhosis. This study examines the role of onion peel quercetin (OPQ) on oxidative stress, liver function and steatosis in ethanol-treated mice over two phases, protective and therapeutic.
Urinary Mycobacterium tuberculosis Antigens Cocktail as a Potential Marker for Differentiating Active and Latent Tuberculosis Patients
Summary: Early secretory antigenic target protein 6-kDa (ESAT-6), culture filtrate 10-kDa (CFP- 10), and Mycobacterium tuberculosis (Mtb) 64 (MPT-64) antigens are secreted by actively growing Mtb in active tuberculosis (TB) patients. Increased levels of ESAT-6, CFP-10, and MPT-64 at the site of infection facilitate the entry of antigens into the systemic circulation. These low molecular weight proteins (< 67 kDa) can be excreted into the urine via the kidneys. Therefore, this study evaluated the urinary Mtb antigen cocktail (ESAT-6, CFP-10, and MPT-64) levels in active [pulmonary (P) and extrapulmonary (EP)] TB and latent tuberculosis infections (LTBI) individuals.
Monocytic microparticles enhance proinflammatory cytokine secretion by monocytes and activate endothelial cells
Summary: Monocytic microparticles (mMPs) are microparticles derived from activated human monocytes and play an important role in cell-to-cell communication in the circulation. Endothelial cells also exist in the circulation and are thought to have a complex interaction with the released mMPs. Both mMPs and endothelial cells are important players in inflammation. However, the underlying mechanism exerted by mMPs in modulating monocyte and endothelial cell activation during inflammation remains unclear.
Oral lesions during dermatomyositis treatment: A case report
Summary: Dermatomyositis is an inflammatory autoimmune disease that causes significant muscle damage. The diagnosis and treatment of this disease commonly requires both therapeutic and dental care. This article describes a clinical case of dermatomyositis where the patient has been receiving therapy since 2018. Stable disease remission was achieved with therapy, with dual-energy X-ray absorptiometry (DXA) indicating an improvement in bone tissue parameters. However, despite this remission, the patient experienced progressive dental manifestations (characteristic complaints, presence of oral mucosal lesions, destruction of jawbone structures). The primary cause of these dental manifestations was not found to be local oral cavity factors, suggesting they were the consequence of both disease pathology and steroid treatment that targeted the oral cavity tissues. The collaboration between an internist and dentist contributed to the early diagnosis and prevention of possible complications associated with this disease.
Extranodal primary CD20-negative diffuse large B-cell lymphoma with cytoplasmic p16 expression
Summary: Extranodal primary CD20-negative diffuse large B-cell lymphoma (DLBCL) is a rare tumor. It often presents a diagnostic challenge for pathologists as the morphological features of neoplastic cells are similar to those of undifferentiated carcinoma or sarcoma cells. While several B-cell markers are commonly tested, expanding the panel of B-cell markers is necessary to ascertain definitive DLBCL diagnoses and would assist in decisions regarding treatment and prognoses. Several additional markers have been proposed, including several mutated genes commonly expressed in cancer cells, such as c-Myc, Bcl6/c-Myc, Bcl6, Bcl2 (double/triple expressors), as well as cytoplasmic p16.
Stem Cells and Regenerative Medicine
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