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Biomedical Research and Therapy - Vietnamese Journal for Medical Biotechnology and Medicine Incorporating Advances in Regenerative Medicine publishes 12 peer-reviewed issues each year, covering a wide range of biomedical and clinical sciences. Unlike many open-access journals, which charge authors for publication while providing free reader access, Biomedical Research and Therapy does not require fees for subscription, submission, processing, publication, or color image reproduction. Recognized internationally, this journal is committed to disseminating high-quality research in an open-access format, emphasizing basic, translational, and clinical studies on molecular therapeutics and cellular therapies. It includes research involving animal models and clinical trials. The rigorous peer-review process ensures that only scientifically, technically, and ethically sound articles adhering to standard reporting guidelines are published. The journal’s editorial policies are in strict alignment with standards set by the International Committee of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and the Committee on Publication Ethics (COPE), upholding the highest principles of publication ethics.

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Original Research

Impact of Anthropometric and Genetic Factors on Plasma SIRT1 Level in Men with Essential Hypertension and Heart Failure

by Leonidivna S., Oleksandrovych D., Vyacheslavivna M., Mykolayovych Z.

Summary: Sirtuin 1 (SIRT1) emerges as a promising biomarker for heart remodeling in the context of essential arterial hypertension (EAH). Additionally, the levels of certain plasma peptides might signal myocardial fibrosis and the progression of heart failure (HF) in hypertensive patients. Despite this potential, conflicting data exist regarding the marker's diagnostic value in HF patients. This study aims to explore the impact of anthropometric factors on plasma SIRT1 levels in men diagnosed with EAH and HF, considering the rs7069102 single nucleotide polymorphism (SNP) in the SIRT1 gene.

Original Research

Assessing LDL Cholesterol Management and Statin Use in Diabetic Patients: Disparities and Outcomes in a Vietnamese Tertiary Hospital Setting

by Nguyen S., Nguyen D., Dang V., Doan B., Dinh B., Nguyen T., Nguyen C., Pham D.

Summary: The control of low-density lipoprotein (LDL) cholesterol is a critical concern, especially for patients with diabetes, where the use of statins is essential. Despite this necessity, actual treatment practices and the achievement of LDL cholesterol targets are often suboptimal. This study aimed to assess the rate of LDL cholesterol goal attainment and examine statin prescribing habits within the cardiology and endocrinology departments of a tertiary hospital in Ho Chi Minh City, Vietnam.


Harnessing Immune Checkpoint Inhibitors Against Gastric Cancer: Charting the Course to Expanded Therapeutic Benefit

by Chung D., Tung D., Dung T.

Summary: Cancer immunotherapy has become a groundbreaking approach in treatment, with immune checkpoint inhibitors (ICIs) showing exceptional success in blocking the pathways that tumors use to escape immune detection. This review delves into the clinical significance and predictive power of ICIs in the treatment of gastric cancer. It introduces ICIs, explaining their mechanisms of action, reviews key findings from critical trials, and discusses the role of programmed death ligand-1 (PDL1) testing as a potential biomarker for selecting suitable patients. The review also addresses the limitations of PD-L1 testing, while highlighting emerging predictive markers and ongoing research aimed at discovering novel biomarkers, optimizing therapeutic combinations, characterizing the tumor microenvironment, and understanding mechanisms of resistance to therapy. This effort to optimize ICIs aims to extend their significant clinical benefits to a larger group of patients with gastric cancer. In summary, this review provides specialists with an updated overview of the advancements in employing immunotherapy against gastric cancer and outlines the path towards enhancing patient outcomes through continuous research and the refinement of biomarkers.

Case report

Autologous bone marrow-derived mesenchymal stem cells and endothelial progenitor cells transplantation showed potential benefits for type 2 diabetes mellitus Filipino patients: a case series

by Guzman M., S., A. D., Apelado M., P., B. Panuelos J., P. Heralde III F., M. Relacion P., R. Bilbao A., B. Tan-Liu N., S. Barzaga M. T. A.

Summary: Type 2 diabetes mellitus (T2DM) is a serious metabolic disorder characterized by hyperglycemia and insulin resistance. Long-standing T2DM may lead to various macro- and microvascular complications such as diabetic nephropathy, neuropathy, and retinopathy. Currently available treatments for T2DM target high plasma glucose levels but do not address T2DM-associated complications. In this report, the therapeutic application of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) transplantation in improving diabetic blood monitoring parameters among selected T2DM patients was investigated.


Detection of COVID-19 Patients through SARS-CoV-2 Antigen Assay using Chemiluminescence Immunoassay: Comparison to RT-PCR Method

by Phu T., Trong Tin T., Phuong Mai L., Cong Tri T., Quoc Viet V., Hoai Cuong L., Ngoc Truong N., Thi Nam Phuong N., Van Thanh N., Tuan Khanh T.

Summary: Accurate and reliable diagnostic tools are essential in effectively managing infectious diseases during the ongoing global COVID-19 pandemic. For this study, the RT-PCR assay was used as the reference method, and the objective was to determine the concordance rate, sensitivity, and specificity of the SARS-CoV-2 antigen assay (SARS-CoV-2 Ag) using the chemiluminescence immunoassay (CLEIA) technique for identifying COVID-19 patients.

Original Research

Kaempferol Rescues Vascular Endothelial Ferroptosis by Inhibiting Lipid Peroxidation

by Wen L., Zhang W.,-y., Wang L.,-s., Xiao F.-j.

Summary: The vascular endothelium plays a pivotal role in maintaining vascular function and physiological balance. The degradation and injury of endothelial cells are critical pathological events in the progression of vascular diseases, leading to cell death. One such cell death mechanism, ferroptosis, is an iron-dependent form of necrosis characterized by extensive lipid peroxidation-mediated membrane damage and the toxic effects of iron and lipid peroxidation. Kaempferol, a flavonoid, is celebrated for its antioxidant, anti-inflammatory, and anti-cancer properties. Despite these benefits, the impact of Kaempferol on endothelial cell ferroptosis and its potential therapeutic applications in vascular diseases have yet to be fully elucidated.

Original Research

Large-scale separation and purification of exosomes using ionexchange chromatography

by Zhang W.,-y., Cheng X., Wen L., Du L., Lu Y., Wang L.,-S., Xiao F.-J.

Summary: With the growing interest in exosomes for research and therapeutic applications, there's a critical need for effective enrichment strategies that can isolate exosomes in large quantities without contaminants. Despite various methods being developed, none have satisfactorily achieved this goal without contamination issues. This study introduces a novel approach for exosome separation - ion-exchange chromatography (IEC) - that leverages the negatively charged phospholipids on the exosomal surface for more effective isolation.

Original Research

The effect of L-arginine in the prevention of preeclampsia and intrauterine growth of the fetus in primigravid women: a randomized clinical trial

by Khansari S., Nasrollahi S., Khazaei S., Darabi R.

Summary: Given the limited research on the effect of L-arginine in preventing preeclampsia and intrauterine growth restriction (IUGR), coupled with the importance of preventing these conditions, this study was conducted to investigate the potential preventative role of L-arginine on preeclampsia and IUGR in primigravida women.

Original Research

Stimulation of Insulin Secretion and Inhibition of KATP Channels by Afzelechin and Coniferaldehyde from Ensete glaucum Seeds

by Hai Trieu L., Phung Hien L., Thi Kim Anh L., Bich Thao L., Minh Khoi N., Thi Thu Huong N., Van Minh L.

Summary: Ensete glaucum seeds have been shown to possess antidiabetic properties. However, the specific hypoglycemic activities of the compounds they contain remain poorly understood. This study aimed to elucidate the hypoglycemic effects of E. glaucum seed compounds and to explore their mechanisms of action, particularly their interaction with pancreatic islets.

Original Research

Immunophenotypic Expression and its Association with Prognostic Factors, Clinical Stages, and Clinical Profiles in Newly Diagnosed Patients with Plasma Cell Myeloma: Insights from Two Tertiary Care Centers

by Ismail N., Pei Chi L., Nik Yusoff N., R., M., Mohamed R., Hamzah R., Farid Johan M., Hassan R., Mohamed Yusoff S.

Summary: Plasma cell myeloma (PCM) is an incurable clonal neoplasm of plasma cells, which typically presents a poor prognosis. This study aimed to determine the clinical profile of newly diagnosed plasma cell myeloma cases in two tertiary care centers in Malaysia and evaluate the association of aberrant immunophenotypic expression with prognostic factors and clinical stages.

Case report

Sarcomatoid Renal Cell Carcinoma: Report of a Large Malignant Tumor with a Review of the Literature

by Naghibzadeh Y., Javadizadeh A., Amirian F., Ramezani M.

Summary: Sarcomatoid renal cell carcinoma is a rare and aggressive kidney tumor with poor prognosis and distinct microscopic features. Traditional modalities versus new targeted therapy are used in different patients with controversial but some promising results.


Genetic predisposition of interleukin-6 (rs1800797) polymorphism in cervical cancer: A Meta-analysis

by Prema A., Kalarani I., Veerabathiran R.

Summary: Cervical cancer is a significant health burden, especially in less developed countries with limited access to HPV vaccines and screening. Dysregulation of immune cells, interleukin-6 (IL-6), and proinflammatory mediators have been implicated in cancer progression. SNPs in the IL-6 gene are thought to influence cervical cancer. A meta-analysis investigated the relationship between the IL-6 rs1800797 polymorphism and cervical cancer risk.

Case report

An Uncommon Presentation of Chronic Myeloid Leukemia: Osteolytic Bone Lesion as the Initial Manifestation

by Zulkeflee R., H., Hassan M., N., Zulkafli Z., Noor N., Husin A., Abdullah A., D., Yusoff S., M., Ramli M., Bahar R., Rahman W., S., W., A., Zawawi N.

Summary: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that typically occurs in the fifth and sixth decades of life with presentations usually confined to hematopoietic tissues—primarily blood, bone marrow, and spleen. However, primary presentation of CML as extramedullary involvement (osteolytic lesion) is extremely rare, occurring in less than 1% of cases.

Original Research

Impact of Antioxidant Therapy on Lipid Peroxidation and Venous Hemodynamics in Women with Pelvic Venous Incompetence

by Darenskaya M., Stupin D., Semendyaev A., Kolesnikov S., Tukhieva D., Kolesnikova L.

Summary: Pelvic varicosity, a subset of pelvic venous incompetence (PVI), is considered a multifactorial, chronic disease with a progressive course. One effective therapeutic approach may be the use of drugs that inhibit oxidative stress (OS) reactions. The aim of this study was to evaluate the effect of an antioxidant complex on the state of the lipid peroxidation system and venous hemodynamic parameters in the treatment of patients with pelvic varicose veins.



Journal Collections

Covid-19 publications
The collections of Covid-19 related articles published by Biomedical Research and Therapy
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Journal Supplements

Conference Abstracts
The collections of abstract book were published by Biomedical Research and Therapy
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Journal Collections


Stem Cells and Regenerative Medicine
The collections of published articles about stem cells as well as regenerative medicine. 
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Special Issues 

Special Issues 
Biomedical Research and Therapy would like to invite guest editors to contribute special issue. 
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Journal Collections

Natural Extract
The collections of published articles about herbal, natural products. 
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Publication Awards

The best original research articles
Every year, all authors published their studies as Original research in Biomedical Research and Therapy can join this awards.
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Editors' quote


Phuc Van Pham, Editor-in-Chief

Biomedical Science is an important scientific field that directly effects to diagnosis, treatment and prevention of diseases. The journal provides an important avenue of publication in translational aspects of biomedical research and therapy spanning from in vitro to preclinical studies, clinical research and commercialization.


Biomedical Research and Therapy (ISSN 2198-4093) is the official journal of Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.

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