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Morin: a promising nutraceutical therapy for modulation of the NF-ÎşB/NOX-2/IL-6/HO-1 signaling pathways in paracetamol-induced liver toxicity
by Kamal
G.,
Nasr
M. Y.
Hussein
M.,
Abdel-Aziz
A.,
Fayed
A. M.
Summary: Paracetamol overdose potentially causes liver injury. This study aimed to evaluate the impact of morin against paracetamol overdose-induced hepatotoxicity.
Exosomes from human adipose-derived stem cells promoted the expression of angiogenic factors in endothelial cells
by Tran
X.,-Q.,
Vu
B.-N.
Summary: In regenerative medicine, human adipose tissue–derived mesenchymal stem cells (hadMSCs) have exhibited tremendous promise as an efficient approach to chronic cardiovascular diseases. Noble effects of mesenchymal stem cells (MSCs) have been acknowledged to contribute to not only cellular engraftment and response to the site of injury but also paracrine action via the release of extracellular vesicles, notably exosomes. This study aimed to investigate the effects of exosomes from hadMSCs (hadMSC-Exo) on the angiogenesis of endothelial cells.
Silver nanoparticles synthesized using Tualang honey ameliorate seizures, locomotor activity, and memory function in KA-induced status epilepticus in male rats
by Hasim
H.,
Mohamed Salam
S., K., N.,
Rao
P., V.,
Muthuraju
S.,
Muzaimi
M.,
Asari
M. A.
Summary: In recent years, green synthesis of silver nanoparticles using natural products has been increasingly utilized in the biomedical field as a therapeutic approach for managing neurodegenerative diseases. This study aimed to determine the effects of silver nanoparticles synthesized using Tualang honey (THSN) on seizure activity and locomotor and memory functions in rats after kainic acid (KA) induction.
CAPE Improves Vanin-1/AKT/miRNA-203 Signaling Pathways in DSS-induced Ulcerative Colitis
by Elmoghazy
H.,
Hussein
M.,
Abdel-Aziz
A.,
Elmasry
S.,
Metwaly
A.
Summary: Ulcerative colitis (UC) and other inflammatory bowel diseases (IBDs) are common chronic, inflammatory gastrointestinal diseases. Due to their antioxidant, anti-inflammatory, and antibacterial properties, polyphenols are beneficial in the treatment of IBD. Caffeine acid phenethyl ester (CAPE) has been shown to have cytotoxic, antibacterial, antioxidant, and anti-inflammatory effects. This study focuses on the biochemical and molecular levels of the mode of action of CAPE in DSS-induced UC in rats.
Light-Chain Multiple Myeloma Presenting as a Bone Tumor in the Right Knee Joint – a Case Report
by Choudhary
N.,
Raju
K.,
Shanthappa
A., H.,
Prasad
C., R.,
Agarwal
S.
Summary: Myeloma is the neoplastic proliferation of plasma cells. The peak age of onset of this disease is the seventh decade, and it is rare in young patients. Myeloma usually presents as lytic lesions in axial bones and rarely present as a joint disease. Usually, the tumor cells secrete monoclonal immunoglobulins. Non-secretory myeloma is a rare clinical entity. The incidence of light-chain myeloma is 16 – 20 % among all multiple myelomas, and the more common subtype is the lambda chain type. We present a case of kappa light chain-type myeloma in a 29-year-old male with the presenting lesion in the right knee joint. The case is presented for its rarity due to the age of patient, presentation, and type of myeloma.
Art of using maintenance therapy in a patient with metastatic colon cancer harboring RAS-wt/BRAF V600E
by Payandeh
M.,
Karami
A.,
Karami
N.
Summary: Colorectal cancer is one of the most common malignancies with a high rate of liver metastasis, and various gene mutations have been proven to be involved in its pathogenesis. One of them is BRAF gene mutations, the most frequent of which—V600E—has a poor prognosis in patients with colon cancer.
Neutrophil-to-lymphocyte ratio as a promising biomarker for the diagnosis of psoriasis in Pakistan
by Nawaz
B.,
Khawar
M., B.,
Afzal
A.,
Aman
S.,
Hamid
S., E.,
Abbasi
M., H.,
Sheikh
N.,
Shah
S., S.,
Rafiq
M.,
Azam
F.,
Mehmood
R.
Summary: Psoriasis is a skin inflammation characterized by papules and plaques on the skin surface. Almost 125 million people are affected by psoriasis worldwide. This study aimed to evaluate whether the neutrophil-to-lymphocyte ratio (NLR) can be used as a biomarker for the diagnosis of psoriasis.
The outcomes of mechanical thrombectomy in patients with acute stroke with and without intravenous injection of tissue plasminogen activator
by Khazaei
M.,
Mohammadi
R., M.,
Mazaheri
S.,
Ghiasian
M.,
Khazaei
S.
Summary: Stroke is a major health problem and leading cause of mortality worldwide. This study aimed to evaluate the consequences of intravascular interventions in patients with acute ischemic stroke with and without intravenous tissue plasminogen activator (tPA) injection.
Oxidative status, carbohydrate, and lipid metabolism indicators in saliva and blood serum of type 1 diabetes mellitus patients
by Cheprasova
A.,
Popov
S.,
Pashkov
A.,
Verevkin
A.,
Kryl’skii
E.,
Mittova
V.
Summary: Diabetes mellitus (DM) is an acute biomedical problem whose prevalence in the Russian Federation and elsewhere continues to rise. Regular blood glucose monitoring in patients with DM requires the identification of new approaches for the non-invasive assessment of glycemic parameters. Previous studies assessing the relationship between the biochemical composition of saliva and blood plasma found saliva suitable for DM monitoring. In this study, we assessed correlations between oxidative status and carbohydrate and lipid metabolism indicators in saliva and blood serum of patients with type 1 DM (T1DM).
Guar gum nanoparticles ameliorate inflammatory damage in a preclinical mouse model of collagen II induced arthritis
by Ghosh
N.,
Mitra
S.,
Banerjee
E. R.
Summary: Rheumatoid arthritis (RA) is a bone disorder causing inflammation of synovial lining followed by production of proinflammatory cytokines at the same site. The synovial hyperplasia is also mediated by the infiltration of lymphocytes, macrophages and other inflammatory cells. The available drugs for RA shows temporary recovery and some are associated with side effects. Here we have used surface functionalized guar gum nanoparticles (GN) to ameliorate disease pathology using collagen II (CII) induced arthritis model in C57BL/6 mice.
Dysregulated Metabolism in Cancer
by Isa
A.
Summary: Metabolism describes the cellular bioenergetic pathways that provide energy and macromolecules for protein, lipid, and nucleic acid syntheses. In cancer, malignant cells alter the metabolic pathways to acquire nutrients needed for proliferation and survival. The various metabolic modifications exhibited by cancer cells include aerobic glycolysis, decreased oxidative phosphorylation, and elevated production of biosynthetic intermediates. To support the increasing need for these metabolic modifications, cancer cells increase the expressions of plasma membrane transporters and enzymes involved in the metabolic pathways. Additionally, some cancer cells escape chemotherapy treatment by reprogramming their metabolic activities. This chemotherapy-induced resistance mechanism allows malignant cells to promote their survival as well as to provide defense against cell damage by engaging various metabolic shunt pathways. Therefore, understanding metabolic reprogramming in cancer may provide useful information that can further be exploited to strategize potential treatment interventions and subsequently foster better outcomes among patients with cancer.
Huge Papillary Renal Cell Carcinoma with Extension to the Inferior Vena Cava: A Case Report
by Azizi
M.,
Sadeghi
M.,
Amirian
F.,
Mohammadi
K.,
Ramezani
M.
Summary: Papillary renal cell carcinoma (PRCC), the second most common type of renal cancer, is a heterogeneous disease with diverse molecular and clinical characteristics. Involvement of the inferior vena cava (IVC) is a predictor of poor prognosis; however, literature is scarce in this regard.
Prevalence, treatment, and 1-year outcomes of heart failure with mid-range ejection fraction
by Nguyen
S., V.,
Do
T., M.,
Tran
T., X.,
Nguyen
T., T.,
Pham
D. T. M.
Summary: The prevalence of patients with heart failure with mid-range ejection fraction (HFmrEF) remains unchanged regardless of healthcare strategies. HFmrEF has mixed characteristics of heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). The treatment of HFmrEF was recommended to be similar to the treatment of HFpEF in the 2016 guidelines of the European Society of Cardiology (ESC) but was changed to those of HFrEF in the 2021 version. Objective: To describe the clinical characteristics of inpatients with HFmrEF with a focus on treatment practices.
The Value of DPAS in the Detection of Breast Malignant Cells
by Idris
A., A., A.,
Suliman
A., A., M.,
Adam
E., A.,
Husain
N. E. O. S.
Summary: Fine-needle aspiration (FNA) has become an essential, critical test for breast masses. This study aimed to determine the value of diastase-resistant periodic acid-Schiff (DPAS) staining in the detection of malignant breast cells.
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Phuc Van Pham, Editor-in-Chief
Affiliation
Why publish with Biomedical Research and Therapy
Journal Information
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ISSN: 2198-4093
DOI Prefix: 10.15419
Indexed: Web of Science (ESCI, Clarivate Analytics), Embase (Elsevier), Google Scholar
Annual Journal Metrics
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Speed
26 days to first decision for all manuscripts
37 days from submission to acceptance
12 days from acceptance to publicationJournal Citation Indicator (JCI)
0.16 - Journal Citation IndicatorJournal Impact Factor (JIF)
Not yetAcceptance Rate
54.32%
Editor-in-Chief
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Phuc Van Pham, Vietnam National University Ho Chi Minh City, Viet Nam
Contact
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Editor-in-Chief: pvphuc@bmrat.org; pvphuc@hcmus.edu.vn; phucpham@sci.edu.vn, pvphuc@vnuhcm.edu.vn
Support Team: support@bmrat.org; contact@bmrat.org
Managing Editor: managingeditor@bmrat.org
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