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latest articles
Advanced esophageal squamous cell carcinoma with rare metastases to the thyroid gland and supraclavicular lymph node: a case report
by Nguyen
D.,
Dao
H.,
Dinh
T.,
Vu
D.,
Dang
C.
Summary: Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with a propensity for metastatic spread. Metastasis to the thyroid gland is a rare occurrence, with few reported cases in the literature. This report presents a rare case of advanced ESCC with metastases to the thyroid and supraclavicular lymph node, highlighting the importance of considering metastatic disease in patients with unusual thyroid lesions and a history of ESCC.
Evaluating the efficacy of preoperative radiotherapy in breast cancer patients non-responsive to neoadjuvant chemotherapy: A clinical trial
by Muslumanoglu
M.,
Ozkurt
E.,
Emiroglu
S.,
Ibis
K.,
Abuaisha
A.,
Tukenmez
M.,
Cabioglu
N.,
Igci
A.,
Ozmen
V.,
Kucucuk
N.
Summary: Neoadjuvant chemotherapy (NACT) is a prevalent treatment strategy for patients with locally advanced breast cancer (LABC). Achieving a pathologic complete response (pCR) is a critical determinant of favorable outcomes. To enhance response rates, some clinicians have incorporated radiotherapy (RT) prior to surgery.
Application of artificial intelligence in the diagnosis of haematological disorders
by Almbaidin
H.,
Abeden
Z.,
Alhawamdeh
M.,
Nazman
H., N., M.,
Hamdani
H., Y.,
Yusoff
N., M.,
Isa
A.
Summary: There is a broad spectrum of hematological diseases, and their origins can be attributed to a variety of factors, including genetic abnormalities such as leukemia, sickle cell anemia (SCA), and thalassemia, as well as conditions associated with the lack of certain blood components, such as iron deficiency anemia (IDA). Testing and analyzing for hematological disorders is intensive in terms of time, effort, and labor. Additionally, there is a higher chance of human error and variance during the manual examination and analysis of the test samples, depending on the expertise, skills, and experience of the examiner. Recent developments in artificial intelligence (AI), such as Machine Learning (ML) and Deep Learning (DL) algorithms—such as Random Forest (RF), Decision Tree (DT), and Support Vector Machine (SVM)—have demonstrated the considerable contribution they could make to more rapid and accurate disease diagnosis, detection, and classification. An increasing number of hematological diseases are being diagnosed using AI techniques, which combine tabular and image data to eliminate human error, generate more precise results, and decrease the time required for diagnosis. This review discusses several widely utilized AI disease evaluation algorithms and their applicability to hematological disorders. Additionally, we highlight key challenges such as the lack of accessible clinical data, which inhibits the implementation of AI in the field of medicine.
Exosomes derived from mesenchymal stem cells: A novel agent for skin aging treatment
by Nguyen
S.
Summary: Skin aging, influenced by both intrinsic and extrinsic factors, leads to structural and functional deterioration characterized by wrinkles, reduced elasticity, and impaired wound healing. Mesenchymal stem cell-derived exosomes (MSC-exos) have emerged as a promising therapeutic option, offering multifaceted benefits for skin rejuvenation. These nano-sized extracellular vesicles exhibit exceptional bioavailability, biocompatibility, and immunomodulatory properties, addressing challenges associated with conventional treatments. MSC-exos enhance collagen synthesis, modulate inflammation, and promote angiogenesis through molecular pathways such as PI3K/Akt and Notch signaling. Furthermore, their ability to deliver bioactive molecules precisely to target cells underscores their therapeutic potential in skin repair and anti-aging applications. However, challenges remain regarding large-scale production, targeting efficiency, and regulatory frameworks, warranting further research to translate these innovative therapies into clinical practice.
Therapeutic potentials of mesenchymal stem cells for cognitive impairment in stroke: Evidence from preclinical studies
by Roza
P.,
Maryanti
Y.,
.
U.,
Saputra
N., P., K.,
Arfianti
A.
Summary: Stroke is a debilitating neurological disorder that frequently results in cognitive impairments, significantly affecting the quality of life of post-stroke patients. Current therapeutic options for poststroke cognitive impairment (PSCI) are limited. Mesenchymal stem cells (MSCs) have emerged as a promising strategy for enhancing neurological recovery, including cognitive function. This review evaluates the application of MSCs in improving cognitive function in stroke patients, focusing on data from preclinical studies. Approximately 75% of strokes occur in the elderly population, and animal models have been developed to study the effects of MSCs on ischemic stroke in aged rats, as well as in the presence of comorbidities such as hypertension and diabetes. The potential of MSCs to enhance cognitive function following a stroke is believed to involve multiple mechanisms, including the secretion of trophic factors, immunomodulation, differentiation into neural cell types, promotion of angiogenesis, and replacement of damaged cells. However, several challenges remain to be addressed, including a lack of clear understanding of the biological processes contributing to MSC efficacy, standardization of MSC preparation, and determination of optimal treatment protocols. Further studies on the specific mechanisms of action and clinical application of MSCs are required to confirm their therapeutic efficacy for stroke patients. The development of innovative and targeted therapies for PSCI will ultimately improve the quality of life for stroke survivors.
Primary evaluation the effects of Boesenbergia pandurata ethanol extract on etoposide-induced senescence in fibroblasts
by Vo
P.,
Do
N.,
Nguyen
S.
Summary: Cellular senescence is an extensively researched issue aimed at influencing the aging process. A novel research direction involves studying the potential of plant extracts on this process. Boesenbergia pandurata (Roxb.) Schltr, also known as Boesenbergia rotunda (L.) Mansf, is a herb with significant potential for research into its effects on aging. Furthermore, it is crucial to study cellular senescence models to accurately assess the impact of various agents on the aging process.
The relationship between MBL2 levels and NLRP3 in acute ischemic stroke: Insights from a proteomics study
by Zhu
B.,
Li
X.,
Tian
Y.,
Yang
H.,
Wu
M.,
Wang
S.,
Wang
B.,
Zhao
Z.
Summary: Inflammation plays a pivotal role in the pathogenesis of stroke. However, the proteins that initiate inflammatory responses remain unclear. In this study, we utilize proteomics to identify the core protein in acute ischemic stroke (AIS) patients and verify the relationship of the protein with NOD-like receptor protein 3 (NLRP3).
Hemocyanin is a major allergen in local mud crab Scylla paramamosain in Viet Nam
by Le
K.,-M.,
Trinh
H., K., T.,
Van
T., N., V.,
Pham
D., L.,
Nguyen
H., T.,
Tran
T.,-T.,
Thi
M., N., T.,
Pham
B., Y.,
Pham
D. M.
Summary: Shellfish allergy is prevalent in coastal countries across Asia. Despite crab being a popular dish, there is limited knowledge about the features of crab allergy in Viet Nam. This study aims to identify the IgE-binding allergens in the local crab species, Scylla paramamosain (S. paramamosain).
Platelet-rich plasma therapy for meibomian gland dysfunction and dry eye: A mini review
by Nguyen
S.,
Pham
P.
Summary: A common eye condition known as dry eye syndrome is characterized by insufficient tear production or rapid tear evaporation, causing dryness, irritation, and pain. A common etiological cause for dry eye disease (DED) that affects both the composition and production of tears is meibomian gland dysfunction (MGD). Meibum, an oily substance produced by the meibomian glands, is essential for preventing tear evaporation. The temporary alleviation offered by standard dry eye therapies has prompted researchers to investigate new therapeutic modalities. Platelet-rich plasma (PRP) therapy has been identified as a viable approach for stimulating meibomian gland activity and improving tear production in dry eye patients. Highly concentrated platelets and growth factors found in PRP are essential for promoting tissue regeneration and accelerating the healing process. By the application or injection of PRP in the affected region, the growth factors could stimulate the production and release of meibum, thereby improving the functionality of the meibomian glands and reinstating the stability of the tear film. The objective of this review article is to conduct a comprehensive analysis of clinical evidence supporting the utilization of PRP therapy in managing MGD and dry eye syndrome. Several studies have demonstrated the efficacy of PRP therapy in enhancing meibomian gland function, mitigating ocular surface inflammation, and alleviating symptoms associated with dry eye. Based on the research outcomes, it has been determined that PRP therapy exhibits potential efficacy as a novel intervention for treating dry eye syndrome. This therapeutic approach demonstrates the ability to enhance the health of the ocular surface and target the fundamental etiological factors associated with this condition. Additional research and investigation are required to ascertain the optimal protocols and long-term efficacy of PRP therapy in treating dry eye and MGD. In conclusion, PRP therapy represents a promising and effective treatment option for patients suffering from dry eye syndrome and MGD, offering significant improvements in ocular surface health and patient quality of life.
miRNAs in Melanoma: Diagnostic, prognostic, and therapeutic strategies
by Evyapan
G.,
Ozdem
B.,
Aksoy
G.
Summary: Melanoma is a highly aggressive and deadly form of skin cancer, with its incidence and mortality rates increasing significantly worldwide. Recent research suggests that miRNA-based therapies could help improve outcomes for melanoma patients by controlling gene expression at the posttranscriptional level, which affects how the tumor grows and spreads. This review aims to examine the role of microRNAs (miRNAs) in melanoma progression, highlighting their potential as therapeutic targets and exploring how they may be utilized in diagnostic and prognostic processes.
Results response of neoadjuvant chemotherapy for stage III breast carcinoma at Viet Nam National Cancer Hospital
by Thien
N.,
Quang
L.,
Trung
N.
Summary: To characterize the clinical and paraclinical features of stage III breast carcinoma (BC) and evaluate the response to neoadjuvant chemotherapy (NAC).
Platelet rich plasma driven changes in hepatic glycogen metabolism and hepato-histological assessment in diabetic mice
by Arif
A.,
Shakir
M.,
Shahzad
A.,
Kawish
N.,
Sheikh
N.,
Abbasi
M.,
Khawar
M.
Summary: Platelet-rich plasma (PRP) emerges as a promising therapy, exhibiting noticeable anti-diabetic potential. Nevertheless, the precise underlying mechanism remains enigmatic. In the current investigation, we aimed to scrutinize the potential therapeutic ramifications of PRP in alloxan-induced diabetic mice, with a particular focus on its modulation of glycogen metabolism and glucose transport.
Association of P73, BMP15, and GDF9 gene polymorphisms with diminished ovarian reserve
by Ghasemifar
S.,
Kalantar
S., M.,
Babakhanzadeh
E.,
Mirabutalebi
S., H.,
Khodadadian
A.,
Nazari
M.,
Ghasemi
N.
Summary: Diminished ovarian reserve (DOR) is a condition in which the quantity or quality of oocytes results in impaired fertility. The prevalence of DOR in infertile women is estimated to be around 10%. Our aim was to investigate the polymorphisms rs3810682, rs10491279, and rs4648551 in association with the genes BMP15, GDF9, and p73 in patients with DOR and control samples.
A laboratory study on N-acetyl cysteine in SSP+ modulating oxidative stress and delaying the progression of storage lesion in platelets
by Rajanand
M.,
Ananthakrishna
A.,
Rajashekaraiah
V.
Summary: Oxidative stress (OS) contributes to platelet storage lesion (PSL) and can be attenuated by using antioxidant additives in the storage solution. N-acetyl cysteine (NAC), a thiolcontaining antioxidant, scavenges reactive oxygen species (ROS) directly, upregulates antioxidant defenses, and has anti-apoptotic properties. This study explores the effect of the antioxidant additive NAC on platelets during storage.
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Editors' quote
Phuc Van Pham, Editor-in-Chief
Affiliation
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Journal Information
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ISSN: 2198-4093
DOI Prefix: 10.15419
Indexed: Web of Science (ESCI, Clarivate Analytics), Scopus, Embase (Elsevier), Asean Citation Index, Google Scholar
Journal Metrics
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Speed (Median)
35 days to first decision for all manuscripts
55 days from submission to acceptance
15 days from acceptance to publicationCitation metrics
0.14 Journal Citation Indicator (JCI, 2023)
0.6 Journal Impact Factor (JIF, 2023)0.8 5-year Impact Factor (JIF, 2023)
Acceptance Rate
35.20%
Editor-in-Chief
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Phuc Van Pham, Vietnam National University Ho Chi Minh City, Viet Nam
Contact
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Editor-in-Chief: [email protected]; [email protected]
Support Team: [email protected]; [email protected]
Managing Editor: [email protected]
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